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March 15, 2025 The Lancet
A comprehensive new study published in The Lancet has identified five distinct subtypes of Long COVID, each with different underlying mechanisms and symptom clusters. Researchers analyzed data from over 40,000 patients across 20 countries to create this new classification system, which could lead to more targeted treatment approaches.
The subtypes include neurological-dominant, respiratory-dominant, cardiovascular-dominant, immune-dysregulation-dominant, and multi-system variants. The study authors hope this classification will help clinicians better diagnose and treat long COVID patients.
Read Full ArticleMarch 10, 2025 JAMA Network
A phase 3 clinical trial for a novel therapeutic approach targeting mitochondrial function has shown significant improvements in fatigue levels among Long COVID patients. The drug, which aims to improve cellular energy production, demonstrated a 40% reduction in fatigue severity compared to placebo in a study involving 600 participants.
The treatment could offer new hope for one of the most common and debilitating Long COVID symptoms. Regulatory approval may be sought by the end of the year if additional safety data remains positive.
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